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Sei Sasaki Selected Research

Nephrogenic Diabetes Insipidus

12/2018AKAPs-PKA disruptors increase AQP2 activity independently of vasopressin in a model of nephrogenic diabetes insipidus.
11/2016Wnt5a induces renal AQP2 expression by activating calcineurin signalling pathway.
6/2013Hereditary nephrogenic diabetes insipidus in Japanese patients: analysis of 78 families and report of 22 new mutations in AVPR2 and AQP2.
5/2008Immunological profile in a family with nephrogenic diabetes insipidus with a novel 11 kb deletion in AVPR2 and ARHGAP4 genes.
7/2007Aquaporin-2 protein dynamics within the cell.
5/2007A case of nephrogenic diabetes insipidus with a novel missense mutation in the AVPR2 gene.
1/2007Lithium effectively complements vasopressin V2 receptor antagonist in the treatment of hyponatraemia of SIADH rats.
9/2006Pathogenesis and treatment of autosomal-dominant nephrogenic diabetes insipidus caused by an aquaporin 2 mutation.
2/2006[Nephrogenic diabetes insipidus: Pathogenesis, pathophysiology, and therapy].
6/2004Clinical characteristics of eight patients with congenital nephrogenic diabetes insipidus.
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Sei Sasaki Research Topics

Disease

19Pseudohypoaldosteronism
11/2015 - 10/2006
18Nephrogenic Diabetes Insipidus
12/2018 - 06/2000
12Hypertension (High Blood Pressure)
10/2014 - 01/2005
8Chronic Renal Insufficiency
06/2017 - 03/2012
8Ischemia
11/2012 - 05/2003
4Nephrotic Syndrome (Syndrome, Nephrotic)
01/2021 - 03/2003
4Renal Insufficiency (Renal Failure)
01/2021 - 12/2004
4Hyperkalemia
10/2014 - 07/2005
4Gitelman Syndrome
10/2013 - 11/2006
4Hypotension (Low Blood Pressure)
12/2010 - 01/2006
4Dehydration (Water Stress)
12/2008 - 01/2003
4Acute Kidney Injury (Acute Renal Failure)
12/2007 - 12/2004
3Inappropriate ADH Syndrome (SIADH)
11/2021 - 05/2005
3Hyponatremia
11/2021 - 05/2005
3Heart Failure
11/2021 - 01/2006
3Bone Diseases (Bone Disease)
06/2017 - 02/2009
3Kidney Diseases (Kidney Disease)
02/2017 - 09/2012
3Fibrosis (Cirrhosis)
06/2016 - 01/2002
3Anemia
10/2014 - 12/2004
3Infections
12/2013 - 05/2008
3Glomerulonephritis
06/2013 - 01/2007
3Alkalosis
08/2011 - 10/2009
3Hypokalemia
08/2011 - 10/2009
2Liver Cirrhosis (Hepatic Cirrhosis)
11/2021 - 01/2006
2Interstitial Nephritis (Tubulointerstitial Nephritis)
01/2021 - 06/2013
2Hemorrhage
01/2017 - 01/2007
2Acidosis
10/2014 - 10/2006
2Inborn Genetic Diseases (Disease, Hereditary)
10/2014 - 06/2013
2Chronic Kidney Failure (Chronic Renal Failure)
12/2013 - 12/2004
2Proteinuria
11/2013 - 10/2011
2Neoplasms (Cancer)
08/2012 - 01/2005
2Hypoxia (Hypoxemia)
04/2010 - 12/2004
2Bipolar Disorder (Manic Depressive Psychosis)
01/2007 - 01/2006
2Body Weight (Weight, Body)
01/2006 - 01/2003
2Cardiovascular Diseases (Cardiovascular Disease)
08/2005 - 01/2005
2Polyuria
06/2004 - 01/2003
1Renal Cell Carcinoma (Grawitz Tumor)
01/2021
1Acute Tubulointerstitial Nephritis
01/2021
1Lipoid Nephrosis (Glomerulonephritis, Minimal Change)
01/2021
1Wounds and Injuries (Trauma)
01/2021
1Ascites
06/2016
1Iron Deficiencies
09/2015
1Brain Diseases (Brain Disorder)
01/2015
1Hyperammonemia
01/2015

Drug/Important Bio-Agent (IBA)

17Phosphotransferases (Kinase)IBA
11/2015 - 10/2006
15Proteins (Proteins, Gene)FDA Link
02/2017 - 06/2002
12Vasopressins (Vasopressin)IBA
11/2021 - 02/2002
10Aquaporins (Water Channels)IBA
06/2016 - 05/2002
10Lysine (L-Lysine)FDA Link
11/2015 - 12/2008
9Aquaporin 2IBA
06/2013 - 06/2002
7Vasopressin Receptors (Arginine Vasopressin Receptor)IBA
11/2021 - 06/2000
7SaltsIBA
10/2014 - 11/2006
5Alanine (L-Alanine)FDA Link
05/2014 - 11/2010
5Proline (L-Proline)FDA Link
05/2014 - 11/2010
5Arginine Vasopressin (Argipressin)IBA
06/2013 - 06/2004
4SodiumIBA
11/2015 - 01/2006
4Pharmaceutical PreparationsIBA
10/2011 - 12/2004
3Member 3 Solute Carrier Family 12IBA
11/2015 - 01/2013
3Biomarkers (Surrogate Marker)IBA
12/2014 - 12/2005
3Prednisolone (Predate)FDA LinkGeneric
11/2013 - 01/2007
3Glycerol (Glycerine)FDA LinkGeneric
08/2006 - 04/2005
3Messenger RNA (mRNA)IBA
08/2005 - 05/2003
2TolvaptanFDA Link
11/2021 - 06/2016
2GlucocorticoidsIBA
01/2021 - 10/2011
2MineralsIBA
06/2017 - 09/2012
2Vitamin DFDA LinkGeneric
06/2017 - 09/2012
2Serum AlbuminIBA
02/2017 - 01/2005
2ElectrolytesIBA
02/2017 - 11/2010
2CreatinineIBA
06/2016 - 04/2010
2Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA
09/2015 - 09/2013
2SymportersIBA
05/2014 - 01/2006
2AntibodiesIBA
11/2013 - 05/2008
2LipidsIBA
10/2013 - 12/2012
2LDL CholesterolIBA
10/2013 - 12/2012
2Antihypertensive Agents (Antihypertensives)IBA
07/2013 - 01/2006
2AutoantibodiesIBA
06/2013 - 05/2008
2Sevelamer (RenaGel)FDA Link
12/2012 - 02/2009
2Triglycerides (Triacylglycerol)IBA
12/2012 - 04/2005
2CalciumIBA
09/2012 - 01/2010
2ThiazidesIBA
12/2010 - 01/2003
2Bumetanide (Bumex)FDA LinkGeneric
11/2010 - 05/2005
2Immunoglobulin G (IgG)IBA
05/2008 - 05/2008
2Chloride Channels (Chloride Channel)IBA
03/2008 - 08/2002
2AldosteroneIBA
02/2008 - 08/2005
2Cisplatin (Platino)FDA LinkGeneric
08/2006 - 12/2005
2Deamino Arginine Vasopressin (Desmopressin)FDA LinkGeneric
05/2005 - 01/2003
1Tyrosine Kinase InhibitorsIBA
01/2021
1Sorafenib (BAY 43-9006)FDA Link
01/2021
1ChloridesIBA
02/2017
1DNA (Deoxyribonucleic Acid)IBA
02/2017
1DiureticsIBA
06/2016
1Cullin Proteins (Cullins)IBA
10/2015
1IronIBA
09/2015
1AmmoniaIBA
01/2015
1Transaminases (Aminotransferases)IBA
01/2015
1Brain Natriuretic Peptide (Natrecor)FDA Link
12/2014

Therapy/Procedure

11Therapeutics
06/2016 - 01/2002
9Renal Dialysis (Hemodialysis)
01/2015 - 12/2004
3Sodium-Restricted Diet (Diet, Sodium Restricted)
08/2011 - 01/2006
1Sutures (Suture)
01/2017